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Are there any long-term side effects associated with testosterone replacement therapy?

The side effects of testosterone replacement therapy are minimal when care is overseen by an experienced physician. The most proactive method for avoiding complications from therapy involve regularly obtained blood panels from routine lab work. Common side effects include increased bodily oil production, acne, and accelerated male pattern baldness from increased DHT production.  Some less common side effects are polycythemia (elevated hematocrit) and elevated PSA (prostate-specific antigen).  Nominal bumps to hematocrit and PSA are normal during therapy, but in some cases men bump beyond therapeutic ranges (assessed for during blood panels).

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